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How to Play: Arrows: Move Pill - Z/X: Flip Pill

Dr Mario

Dr Mario is a game for the NES where Mario must administer pills into a bottle to eliminate the viruses. The levels start out slow and easy but get considerably harder as you go. To clear a level, eliminate all the viruses. You can choose how hard you want to make the game before playing.
Played 134355 times
More Super Mario Games To Play
  • Super Mario World Plus
    Bowser's brother Mozart (what?) has kidnapped the Princess and all the Yoshis too. Only Mario can save the day!
  • Super Mario 3 Torva
    A complete remake of Super Mario 3 featuring 7 worlds and 95+ levels. Can you save the Princess?
  • Mario Must Die
    Bowser got tired of losing all the time so he hired some devious engineers to design horribly difficult levels
  • Mario In Midgard
    Mario enters the land of Midgard expecting to find Bowser. However, he finds something MUCH worse...
  • Mario World Buried Treasure
    A fun, desert themed Mario hack featuring new enemies and stages to explore as you look for the treasure!
  • Mario Fantasy Adventure
    Choose 4 of 6 heroes to take with you on a quest in this awesome Final Fantasy I rom hack
  • Super Mario Bros
    Relive some old school nostalgia with this epic, classic masterpiece for the NES starring Mario and Luigi!
  • Mario Pinball Land
    When 2 Goombas capture Peach at the funfair, it is up to Mario to save her with the Spherasizer Pinball device!
  • Mario the Archaeologist
    Mario must explore ancient pyramids and old catacombs in search of special treasures for Princess Peach
  • Mario 4 Space Odyssey
    When an alien warns Mario and Luigi of an interstellar threat from outer space, it is up to them to save the world!
  • Mario 3 Fae Earrings Edition
    The sequel to Mario 3 Torva. Features 8 worlds, over 100 new levels, and a few surprises.
  • Mario 3 Coin Jump
    Mario 3 but you get an extra jump if you collect a coin midair. Otherwise, the same as Mario 3.
  • Mario Chronicles
    Mario Chronicles is an awesome and challenging remake of Super Mario Bros 3 for the Nintendo
  • Mario World 2 Yoshis Island
    Explore 6 worlds and over 48 stages as Yoshi tries to keep Baby Mario safe from all the enemies
  • Contra
    How can you not love some old school Contra? Up, up, down, down, left, right, left, right, b, a, start!
  • Princess Peachs Cream
    Starring Princess Peach herself, this difficult rom hack that will test your skills. Can you even beat level 1?
  • Super Mario Land DX
    A rom hack of the original Super Mario Land for Gameboy, this game sports new graphics and color among other things
  • Mario X World 2nd Edition
    The 2nd edition of Mario X World sees Mario begin on a frosty, slippery island of new adventures
  • Mario World Boss Collection
    Fight 77 bosses from SMB 1, 2, 3, World, Zelda, Donkey Kong, Mega Man, and more! No levels, just bosses!
  • Mario Party Advance
    Starring Mario, Luigi, Princess Peach, and Yoshi as they collect minigames and gaddgets from Shroom City
  • Mario Tennis
    A fun tennis game where you can play as Mario, Luigi, Princess, Donkey Kong, Wario, Bowser, and more!
  • Super Mario Bros 3 Mix
    8 new worlds, new bosses, new enemies, new music, and play as Mario, Luigi, or Toad. Another fantastic SMB 3 hack.
  • Mario Bros 2 Mega Mario X
    2 Thwomps accidentally create a magic door to Subcon! Stars Wart, Tryclyde, Clawgrip, Fryguy, Mouser, and Birdo.
  • Super Mario Bros World
    Throw boxes and hurl fireballs in this unique Mario hack for Sega Genesis. Oh and no jumping on enemies in this one!
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